Noggin for the noggin

[Only Natural]

Any thoughts/possibilities on using Noggin in a topical? Any risks?

http://www.clonemyhair.com/hairlossnews/hairlossnews/item90020.html

More info on it and other growth factors here http://www.in-cosmetics.com/ExhibitorLibrary/265/Caregen-catalogue_2.pdf


Also, have you heard anything new about that topical hGH product? I remember asking you about it over at Hairlossfight.com. Doing a search it doesn't look like anyone has bothered to use it in a finished product all this time.  http://www.regeron.com/eng_public_html/public_html/busi.htm

[DrYechiel]

Hello Only Natural,

The ingredients you mentioned may be helpful, in my opinion, maybe as helpful as minoxidil provided they can be administered by an appropriate vehicle which can take them into the scalp and in a concentration which is useful for topical applications. An effective concentration would probably 5-20 times higher than the concentration sold per treatment. The products’ status is peculiar because they have not been tested as drugs (not FDA approved), yet the claims about them (supposedly based on clinical studies, at least for one ingredient) assume medicinal claims. The main problem with very expensive ingredients which are active in ultra-miniscule quantities is that they may not reach the site of action even if the vehicle is great because they will be completely hindered by other ingredients or by debris in the scalp. When we formulate growth factors, we use very high concentrations to give them a chance, but this makes the cost very high and it makes it impractical for mass use. I advise against using needle rollers because it will not help at all. The bleeding and other secretions from the wounded skin will only contribute to hindering the active ingredients even more. Of course, the needles can cause increased wounding, scarring, infection, and increased hair loss. In my opinion, in the concentration sold, it will not make any difference. Its OK to give it a try but if your budget is tight don’t buy it instead of other, useful products. In addition, the shelf life of the product is very short. Don’t believe any statements to the contrary unless they actually conducted such a testing series. I believe that when the cost of such products will be reduced by a factor of about 50x, they can be a useful addition to scalp products for most people. I don’t believe that such products will do more than a good response to minoxidil. There are quite a few products which match or even may surpass the effects of minoxidil (as compared to effect of minoxidil on scalps which respond well to minoxidil) but not by a big margin. A full-scale regrowth product is not yet available and this is not the one. Good luck in experimenting with it but keep the needles away.   

[Only Natural]

Well..they do have a chart that shoes it remains stable for 100 days. Not sure why they stopped there.

10% is the % that is to be used, along with two other ingreds. Added to distilled water for the final product.

If I get the clinical study info, I'll post it.

I don't know if you missed my last question there on the hGH. Maybe it's just cost prohibitive for anyone to use it.

[Only Natural]

Update: From my discussions with somebody at that company...it would not be a good idea to just add it to distilled water.  It seems someone was looking for an easy solution(or an easy buck- the company, that is)..but it just doesn't work that way 

[DrYechiel]

Hello Only Natural,

I had not noticed this posting. I am glad that someone in that company gave you an honest evaluation. Delivery via skin is very complex because the skin is very complex. The vehicle has to overcome restrictions which are not only different from each other but sometimes are opposite to each other, and on top of all these, it is not supposed to affect the skin's integrity. This requires stealth vehicles which can adapt to rapidly changing conditions and carry on with their mission.